dante labs reddit

Their customer service promised me 3 times (incl. Curtis and Portia exit the elevator to find Liz tending to Dante. Generally, no, I would never recommend outside direct-to-consumer genetic testing for medical diagnostics. Anyway: Diving into the VCF files, I had a look at the mean read depth of the reported variants in my vcf file. The average person does not have many genetic risks, however, most people have some risk for medicine related to an adverse reaction. Ask me about: (Almost) anything tech related, programming in general, taking EECS 280/281 early, PC gaming, finding internships, … Great place to people watch by the pool and make sure you try the BBQ pork panini. I'm not exactly an expert in variant calling, however, it does not seem reasonable to me to include variants with a read depth of 1 or 2 or whatever... Back on-topic: Yes, in theory, and in a perfect world, a 30x coverage whole genome (or exome) sequencing would be able to 'diagnose' some disease that is either well studied and/or monogenic in nature. However, they don't. This just makes me very skeptical of their service. Research revealed that this supposedly italian laboratory probably doesn't even sequence anything on their own, they just send it to another lab - apparently after storing it for a year. Interpretation here is not easy. In the rare disease community, Dante Labs is allowing a lot of patients to receive an accurate diagnosis by their specialists. Yes, unfortunately I've heard some not so good things as well, especially that the waiting times for the results can be extremely long. After being updated, Portia orders him taken into an exam room and tasks Liz with calling security and a lab … At Ascension, we listen and provide healthcare that's right for you. Things like 2 or 3 inserts across 30 reads showing as an INS on the VCF. Plus, even if the test is negative you have the right to request your raw data in case you do want to study it yourself, and it will be better quality than from a DTC lab. Others are more commonly a result of small insertions and deletions, which require use of a test such as chromosomal microarray. No one would expect to loose 50% of the data, to just get a median read depth of just 15...) Additionally they do not seem to filter their called variants at all. Are there helpful tools for this that are free and fairly easy to use? When I asked back (using 3 modes of contact, e-mail, e-mail to CEO, and facebook chat) they chose to ignore my request as I had hard evidence and they once again keep on promising things they cannot actualy fulfill. 9 weeks later and I had not received anything. I contacted customer support around four-ish times IIRC, to get a response back only once. Reactivity with a commercially available panel of monoclonal anti‐D … I was considering getting it as they were one of the cheapest options for whole exome. It took some time for us (developers of an eHealth application) to receive the results (years ago), however, they are here, and now the question is what to do with them next. But if I can't get a FastQ file, than it just doesn't matter. Food. Value. Unfortunately, I cannot recommend them at all. I can't find the place on the webpage. I am quite disappointed with the average read depth. BALTIMORE (WJZ) — Police are investigating after a Safe Streets advocate and community leader was shot and killed in southeast Baltimore on Sunday. Dante Labs offers reports and raw data within two weeks from receiving the sample back. So it's a pretty high learning curve. Hello, I was wondering if Dante Labs tests (specifically whole exome) will be of any use for medical diagnosis? Correct me if I am wrong. Contact Details Francesco Pennelli contact@dantelabs.com +39 0862 191 0671 Thanks to https://www.iconfinder.com/inipagi for our subreddit icon. Ordered some reports and got them within minutes. For many disorders, we can relatively accurately predict where a mutation might occur and can tailor the type of genetic testing to suit. If someone has already done it I would really appreciate any help you can give me please. I’m hoping this DNA test will show something. Our lab will start the DNA extraction as soon as possible.") Even though they claim a 30x genome coverage, the average read depth seen across all variants is worrisome (I am aware that there are filtering steps and alignment, where reads can get lost, but still. The Princeton Dante Project provides the Latin text, Robert Hollander’s English verse translation, and a variety of other resources for studying the Divine Comedy. I haven't used them so I don't know, but they claim 30x coverage which is the standard for "good enough". Or is this an issue as well? And it's just a lot of hassle at the moment. Dante Labs knows that a significant part of its customer base, the people searching for information about their complete genome, are doing this because they have medical concerns or a family history of disease. Date of visit: May 2015. Dante Labs Introduction. The sequencing includes bioinformatics … Dante Labs. Pronouns: (he/him/his) Major: Computer Science Class Standing: Junior Hometown: Farmington Hills, Michigan Why I teach: I’m always excited to share knowledge with others and educate them on the wonderful field of computer science! Dante Labs should improve their communication and set expectations better. The same approach proved successful in the fight against COVID-19 to provide more precise answers at scale. You'd probably then need to find a genetic counsellor to go through the results with you. Anecdotally I've heard terrible things about dante labs - wouldn't recommend if it's in any way time sensitive. That a disease gets misdiagnosed or missed? I've done a 30x WGS Test from Nebula Genomics before; I got 33x from them. or is this normal? Variant interpretation is practically a discipline in itself. Stopped by Dante's while waiting for the Key West Express and was pleasantly surprised. From your post you do not appear to be very sophisticated in Bioinformatics. I read some horror stories of 8+ months so I decided to pay extra for the 2 week turnaround. Actual knowledge of a particular mutation is generally not helpful for treatment purposes. I ordered my kit around early to mid September or so, and the status thereof is still stuck on 'awaiting your kit.' STUDY DESIGN: Samples identified were those that reacted by automated gel technology and were negative with an FDA‐approved reagent. New comments cannot be posted and votes cannot be cast. I am out of work and struggling with some serious health issues. I second everything this commenter says. What you usually get with WGS are a lot of 'risk variants' that make it more likely for you to express a certain disease, however, their interpretation is very tricky! The turnaround time period begins from when your sample is registered into the lab; Share Tweet Pin it Fancy. They still claim it on their website that they provide download links for "fastq,bam, and vcf" files. About Me . For some reason the DNA Explorer is not showing up like it does for my other kits, but I "subscribed" and expect it might come up later. Good food and a great party atmosphere even in the early afternoon. This subreddit is not affiliated with Dante Labs Inc. I've had the exact same experience. Dante Labs is based out of L’Aquila, Italy. Anyone interested in the service, based on DL results? Your sample is classified as level A. The median read depth across all reported variants was 15 (16.8 was the mean). As they are experiencing constant delays in delivery their results they keep on offering special sale offerings. So is this also the case for Dante Labs? Danté Jordan is a former member of the Leafly Subject Matter Expert team, and current freelance writer, video producer, and … Press question mark to learn the rest of the keyboard shortcuts. But I never got them. They are obviously cheaper than genetic testing at a hospital, which also have long a long waiting time. If it is not, then I honestly have trouble understanding what the test would even be good for? What kind of issues do you think could arise? Dante intervenes and she injects him instead, causing him to collapse. The new service is possible thanks to the new Illumina-backed, high-throughput, automated sequencing centre that Dante Labs built in Italy, fully dedicated to the classical Whole Genome and the WholeGenomeZ™ sequencing tests. Thus, their prices are a little higher. Obviously I have no experience in genetics myself, so I agree that a geneticist would be the best, the problem is that I live in a place where I would have to travel very far to see one. Press J to jump to the feed. No response L' AQUILA, Italy, July 12, 2019 /PRNewswire/ -- Dante Labs today introduced a new artificial intelligence (AI) tool to create personalized reports from whole genome sequencing data that leverages a person's medical information to identify the most relevant insights across the six billion letters that make up human DNA. I will go to a geneticist eventually. Is the quality the same? Dante labs offer 30x coverage which is good enough for many purposes - but this is an average - so you could get unlucky and have less coverage in the bits you care about. Dante Labs was founded in 2016 by Mattia Capulli and Andrea Riposati after being approached by a friend who was having difficulty finding a whole genome sequencing test. Apart from horrific promises they don't keep or just outright lies, the customer service is horrible, the delay of delivery is ridiculous. Sounds like PCR amplification issues if you're getting some parts of the genome with very high read depths and some with very low - assuming they did a poor job removing duplicate reads - your actual read depth could be much lower than 16.8. Medical grade sequencing and doctors who have gone to school specifically to study this kind of data and know how to interpret it. Doctors can’t figure it out. The new report, “DTC Testing Industry: Global Markets,” provides a comprehensive analysis of the DTC testing market in a global context, including market forecasts and sales through 2025. And how accurate would it be for this purpose? Man, stay away from Dante Labs and their terrible services. DUBLIN, Jan. 26, 2021 /PRNewswire/ -- The "Direct to Consumer Testing Industry: Global Markets" report has been added to ResearchAndMarkets.com's offering.. And there were a lot of variants with a read depth lower than 3 (and a lot with a read depth of 1). Let's say someone wanted to see if they carry a rare mutation that could explain the persons symptoms, sometimes whole exome testing would reveal which disorder the person has. Would be worse if you got nothing at all. They advertised a delivery time of 2 to 9 weeks max. Press J to jump to the feed. This screams cashflow issues! The project with the Press proceeded to the point where the website license for The Complete Writings and Pictures of Dante Gabriel Rossetti: A Hypermedia Research Archive was advertised in Michigan’s fall 1999 catalogue and a site mock—up featured on … Also, I paid for a hard drive with BAM and fastq files and also did not receive this. Dante Labs built Immensa™ as a smart software platform that uses machine learning to advance the interpretation of the human genome with every analysis. What you get. 30x is a general 'good enough' for a research genome, for clinical exomes and gene panels the target coverage is going to be much higher. It's pretty bad. The actions of Dante Labs are irresponsible and dangerous. That said, plenty of people gain comfort from knowing they carry a specific variant. Apart from all the bad business practices: The data you get is underwhelming. There are also the rare few cases where the clinical symptomatology is vague enough, and other testing inadequate enough, such that genetic testing provides the proof a physician needs to initiate treatment. If you do your own sequencing, even if you did find something your doctor can't take medical action without clinical testing to confirm it. At first I've used Dante Labs' VCF file which only contains variant calls differing from reference genome, yet it is incompatible with Promethease, as it treats everything missing as missing data instead of treating it as reference alleles. Dante Jordan. This is obviously quite a complicated task for someone who has no prior experience with genetics. Can you please give me that CEO's email?I am forwarding a warning email to every email account I can find.Their delays are terrible, one of the 2 kits needs a BRCA report because of family history of breast cancer and they don't even have the snp.vcf files ready.Needless to say that I paid for a hard drive in July 4th and got nothing. NEW YORK, April 24, 2017 /PRNewswire/ -- Dante Labs announced today the offer of whole genome sequencing (WGS) and interpretation at only EUR 850 (ca. I can make it even worse: I sent 2 samples at once. What many lay people don't realize is that unless a specific variant is already classified as pathogenic, there's a whole rubric of criteria that goes into predicting whether it's damaging or benign. Service. For example, some disorders are most commonly caused by single nucleotide mutations that can be accurately discovered by Sanger sequencing. There are far too many variables and issues that can arise. I’m around 8 weeks right now since they received it. Even though they claim to offer raw FASTQ and BAM files, I only ever got the VCF files. Unlike Nebula, Dante Labs does not work on a subscription model. Dante Labs' use of AI is a completely new approach to … By using our Services or clicking I agree, you agree to our use of cookies. You really need a medical genetics consultation to make a more logically and financially prudent decision. Yeah, I've seen a LOT of miscalls on my VCF when I go look at my BAM. WSUSOM traces its roots through four predecessor institutions since its founding in 1868. I … People in my advocacy group have received their results (between 3 and 7 months). You'd need to find someone to do the data analysis for you if you're not able to do it yourself. Find a doctor, access your patient portal, pay your bill, or search for a job. They look good so far (they seem to match the phenotype ;). But Dante labs is not a diagnostic test. How long did the whole process take if you did? I have received an email from Dante Labs that my report is ready to download but I can't figure out how to do it. Just a very bad sign of business practice, as this type of decision making appears on all levels of their business. Cookies help us deliver our Services. BACKGROUND: RhD discrepancies between current and historical results are problematic to resolve. Dante labs offer 30x coverage which is good enough for many purposes - but this is an average - so you could get unlucky and have less coverage in the bits you care about. In terms of whole exome sequencing, if the mutation is in a coding region (or very close by in some instances), WES will usually work. I've started recommending Dante Labs to other people and was about to recommend it to way more people in my rare disease community but now I'm not so sure abnout it anymore.Especially, as they've also started removing access to raw data files without any further notice and are forcing their customers now to buy an additional subscription to be able to do so. Many labs will also work with you and your doctor to keep your copays to a minimum. But there are plenty of pathogenic variants for various disorders that exist in non-coding regions that would be entirely missed by WES. the CEO himself) that I'll get my bam+fastq files with a downloadlink. What if you could have the DL meds panel in an app that is related to your home pharmacy inventory? Anecdotally I've heard terrible things about dante labs - wouldn't recommend if it's in any way time sensitive. CAMBRIDGE & BIRMINGHAM, England & L’AQUILA, Italy--(BUSINESS WIRE)-- Dante Labs, a pioneer and leader in genomic testing, Cambridge Cancer Genomics (CCG.ai), a software developer specialising in data-driven precision oncology, and Nonacus, a provider of genetic testing products for precision medicine and liquid biopsy, today announced that they have … With no modification of business practices, I expect dante labs to go bankrupt in some years. ‍ Quick Facts: Company Name: Nebula Genomics, Inc. Foundation Year: 2016 Location: San Francisco, California Website: Nebula.org ‍Monthly Visits: 39,660 (Updated on Feb 2020, SimilarWeb) Number of Databases: Unknown Nebula Genomics started as an idea to help users manage their genomic data using the power of blockchain technology. You are correct that I am not sophisticated in this topic, but since they provide these tests for the average customer I was thinking they might provide some helpful tools to help interpret the results. In this Italian center of technology, Dante Labs has created a fully-certified lab for sequencing and analyzing whole-genome data. For one, the data got back to me 5 months after, the other, now 10 months later, isn't anywhere to be found. But I also thought that whole exome testing is what they also do at the hospital if they are trying to find an unknown genetic disease? I just got my genome sequence from Dante Labs. Thanks. Their website seems to be more sluggish than normal, maybe they are getting caught up and sent out a whole bunch of results at once ? It's just a long process. Trying to email or have some form of contact with them... my god what comes back sounds like the lab tech's toddler is in charge of their customer service. The wallet-sized box contained the DNA sampling kit, instructions, and details on how to return my sample back to Dante Labs. I hope Dante improves their turnaround time. In 2020, Dante Labs is headed by CEO Andrea Riposati. Dartmouth’s Dante Lab Reader provides the Italian text and the English translation of Henry Wadsworth Longfellow (1867). Dive even deeper into your DNA at any time For discussion of genetics research (all organisms welcome), case studies/medical genetics, ethical issues, questions for geneticists, etc. I’m just hoping to process moves faster than some of the bad stories I have read on here already. If you want an actual diagnosis, talk to your doctor about a referral to a genetics clinic (unless your doctor has a genetic counselor on staff). They aimed to provide direct to consumer of low cost, full access, whole genome sequencing. I have paid for 30x WGS and only received an average read depth of 8x with a lot of no calls and unmapped regions, very disappointed. Dante Labs is an Italian company which claims to provide whole genome sequencing, both short reads and long reads. Cookies help us deliver our Services. I asked another question on the Dante Labs Facebook Page, well why, when the FAQ says it can be downloaded. It is so bad that many tools can't even generate usable reports as too much data is missing and of low quality. Monday October 26, 2020: Today on General Hospital, Dante is disturbed by Maxie's news, Anna and Finn break into the lab, and Jackie refuses to help Robert. Re: Quality. Unless they provide a report on your specific mutation, you'll likely need to go digging into the data yourself to find out. Share This Article Reddit My WGS kit arrived within three days of placing the order. In other words, depending on your specific situation, WES might be entirely unhelpful. $900).While American individuals have been able to access WGS at $1,000, this innovation marks the first time Europeans can access WGS below EUR 1,000.. Now they are having a new deal this year while last year's kits aren't ready yet.I am pissed. How long did it take people to get everything done once it entered “sequencing started”? The investigation of 10 discrepancies is reported here. Dante Labs, Fraud, Filing a complaint I ordered a “30X Whole Genome Sequencing Test” and “ All Panels Package” in September. Thank you for taking the time. https://preview.redd.it/u2l5lie7t6e61.png?width=1920&format=png&auto=webp&s=1af844b59f0111422e768fb87bd556ca651dd502, https://preview.redd.it/l6zvay1ithc61.png?width=1474&format=png&auto=webp&s=187793a3f44bf4ddf0c9d1de4175a3d2eebc4fed. Health Learn about predispositions to over 100 common diseases, including hereditary cancer. Would a test from Dante Labs be able to show if someone indeed did have a genetic disorder? This technology - used to power virtually currenc… I ordered the kit more than 1 year ago and at this point I honestly believe they are running a scam business which is based on offering cheapest prices on the market today while waiting until the cost actually drops so far that they can make profit off it. The Wayne State University School of Medicine (WSUSOM) currently hosts an enrollment of more than 1,500 medical students in undergraduate medical education, master's degree, Ph.D., and M.D.-Ph.D. programs and courses encompass 14 areas of basic science. Do you think the kind of WES testing that Dante Labs provide are complete and at least reliable? But it seems most people recieve their results at the end, so maybe it's not that bad. Having filled the small vial with my saliva (taking around 15 minutes of spitting and cheek massaging) the sample was mixed with a buffer solution when the vial was sealed, and everything was ready for shipping. I have tried to generate 4 reports for 2 different people from Dante Labs' WGS data. Thanks to https://www.iconfinder.com/inipagi for our subreddit icon. Get traffic statistics, SEO keyword opportunities, audience insights, and competitive analytics for Dantelabs. Hi! At the very least it can rule out some things. Just be sure about how certain genetic diagnoses are for the disease of interest. Did anyone on here pay extra for the 2 week turnaround? Genetic testing can be pricey, but you're getting what you're paying for. Most medical genetics testing is done to confirm a clinical diagnosis. It really takes a comprehensive understanding of a particular situation to know what test(s) would work best in any given situation. I AM lucky that I got my BAM and FASTQ from them, as download links, about 4 days after the VCF. Should I file a complaint? or is it of no help at all in this regard? By using our Services or clicking I agree, you agree to our use of cookies. According to U.S. News … 2018-11-28 Dante Labs: Successful DNA extraction - Level A ("We are pleased to confirm you we have successfully completed DNA extraction. Press question mark to learn the rest of the keyboard shortcuts. You can get a file with all of your exome sequence, including any and all mutations you may have in the Exome (Whole Exome is not your entire DNA sequence, but it's the vast majority of the important bits). Dante Labs sequence 100% of your DNA; Get the most advanced and comprehensive Reports on your Health, Nutrition, Fitness, and Drug Reaction; Make an investment for life: Sequence once and get continuous updates as science progresses; Our additional reports cover a vast array of specific health conditions. My average read depth was 23x... much lower than what Dante Labs promised (30x). What marketing strategies does Dantelabs use? 2018-11-11 Dante Labs: Kit received ("We are pleased to confirm you we have received your sample. The Dante Labs Facebook Page told me that I can only get a BAM file via Hard Drive / Flash Drive and I MUST pay $69.00 USD and free delivery.

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